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CAS No.: 59143-60-1

头孢菌素C锌盐 Catalog No. CSN22371

Synonyms: Cephalosporin C (zinc);头孢菌素C锌盐

Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 with an IC50 of 1.1 μM.

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技术信息

生物活性

描述Cephalosporin C zinc salt is a potent inhibitor of SAMHD1 (Sterile alpha motif and histidine-aspartate domain-containing protein 1) with an IC50 of 1.1 ± 0.1 μM, 200-fold more potent than Na+ salt form of Cephalosporin C (ICC50CC-Na = 213 ± 30 μM). Cephalosporin C zinc salt is an antibiotic used to study the effect of transpeptidase expression, binding, and inhibition on bacterial cell wall mucopeptide synthesis. Cephalosporin C zinc salt, as is expected of a Cephalosporin, will disrupt the synthesis of the peptidoglycan layer of bacterial cell walls^[2]. A loss in activity of the zinc-activated enzyme which occurred on prolonged hydrolysis of cephalosporin C was not restored by further addition of zinc^[3]. The minimum inhibitory concentration of cephalosporin C(A) (pyridine) upon penicillinase-producing staphylococci increased 4 to 8-fold with a 500-fold increase in inoculum size; with cephalosporin C there was a 2-fold increase. Cephalosporin C(A) (pyridine) was about 8 times more active than cephalosporin C in protecting mice from an experimental streptococcal infection, nine doses of 6.25 mg/kg affording complete protection^[4].
参考文献

[2] Seamon KJ, Stivers JT. A High-Throughput Enzyme-Coupled Assay for SAMHD1 dNTPase. J Biomol Screen. 2015 Jul;20(6):801-9
[3] Sabath LD, Finland M. Thiol-group binding of zinc to a beta-lactamase of Bacillus cereus: differential effects on enzyme activity with penicillin and cephalosporins as substrates. J Bacteriol. 1968 May;95(5):1513-9
[4] JAGO M, HEATLEY NG. Some biological properties of cephalosporin C and a derivative. Br J Pharmacol Chemother. 1961 Apr;16(2):170-9

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0886 mL
- 10.4432 mL
- 20.8864 mL
- 5 mM
- 0.4177 mL
- 2.0886 mL
- 4.1773 mL
- 10 mM
- 0.2089 mL
- 1.0443 mL
- 2.0886 mL

技术信息

CAS号

59143-60-1

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H19N3O8SZn

运输

蓝冰

分子量

478.81

别名

Cephalosporin C (zinc);头孢菌素C锌盐

溶解度

DMSO	5.0 mg/mL (10.4 mM) warming

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头孢菌素C锌盐 Catalog No. CSN22371

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